The most common form of mesothelioma is "pleural mesothelioma" which deals with the lungs. The symptoms results from pleural effusion which is a collection of fluid between the two layers of the pleura. Some of the symptoms may be difficulty in breathing, weight loss, fever, persistent coughs, and difficulty swallowing.

The second form of mesothelioma cancer is "peritoneal mesothelioma"which deals with the abdomen. The symptoms results from collections of fluids in abdomen called ascites. It causes the swelling of the abdomen, and results in loss of appetite, bowel obstruction, anaemia, fever, and nausea.

The third and the rarest form of mesothelioma is "pericardial mesothelioma"which deals with the heart. The symptoms results from cancer affecting the heart and the cavity that surrounds the heart. Some of the symptoms may be chest pain, shortness of breath, and palpitations.