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Feature Article: |
 |
 Muraglitazar:
A dual peroxisome proliferator-activated receptor agonist
Muraglitazar is a new agent under investigation
for the treatment of patients with type 2 diabetes. It belongs
to a novel class of drugs that target the peroxisome
proliferator-activated receptors, both alpha and gamma subtypes.
Available clinical data describe improvements in glycemic
parameters similar to available thiazolidinediones. Safety data
are limited, but in available abstracts, there are reports of
moderately elevated rates of edema, weight gain, and
hypoglycemia with muraglitazar compared with placebo or
pioglitazone. |
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